2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00360R
    (Rac)-Sograzepide (Standard) 168161-71-5 98%
    (Rac)-Sograzepide is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid.
    (Rac)-Sograzepide (Standard)
  • HY-W008582
    (Z)-Methyl heptadec-10-enoate 75190-82-8 99.64%
    (Z)-Methyl heptadec-10-enoate (Methyl cis-10-heptadecenoate; C17:1 methyl ester) is the ester form of cis-10-heptadecenoic acid. It is a minor fatty acid methyl ester (FAME) component of biodiesel.
    (Z)-Methyl heptadec-10-enoate
  • HY-W009404
    3'-NH2-ddG 66323-49-7 98%
    3'-NH2-ddG (3'-Amino-2',3'-dideoxyguanosine) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-NH2-ddG
  • HY-W010132
    5-Nitrobenzimidazole 94-52-0 99.74%
    5-nitrobenzimidazole is a genotoxic nitro compound and 6-aminopurine (HY-B0152) analogue. 5-nitrobenzimidazole shows a slight inhibitory effect on xanthine oxidase, with an IC50 of 86.84 μM. 5-nitrobenzimidazole can be used in the research of hyperuricemia.
    5-Nitrobenzimidazole
  • HY-W010655
    Fasiglifam hemihydrate 1374598-80-7 98%
    Fasiglifam (TAK-875) hemihydrate is a potent, selective and orally active GPR40 agonist with EC50 of 72 nM. Fasiglifam enhances glucose-dependent insulin secretion and improves hyperglycemia in type 2 diabetic rats. Fasiglifam can induce liver injury.
    Fasiglifam hemihydrate
  • HY-W010667
    (Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate 2190-25-2 98%
    1,3-Dipalmitoyl-2-oleoyl glycerol (1,3-Palmitin-2-Olein; TG(16:0/18:1/16:0)) is a triacylglycerol that contains palmitic acid (HY-N0830) at the sn-1 and sn-3 positions and oleic acid (HY-N1446) at the sn-2 position. It has been found in cocoa butter, Chinese tallow butter, and the palm stearin fraction of palm oil.
    (Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate
  • HY-W011214
    FABP4-IN-6 50257-40-4 98%
    FABP4-IN-6 is a FABP4 inhibitor with an IC50 of 16.8 μM. FABP4-IN-6 can be used in the research of diabetes and atherosclerosis.
    FABP4-IN-6
  • HY-W011334
    Methyl 12-oxooctadecanoate 2380-27-0 98.0%
    Methyl 12-oxooctadecanoate is a fatty acid that can be isolated from the pulp of Livistona decipiens (Palmae), which has anti-hyperlipidemic and anti-ulcer activities.
    Methyl 12-oxooctadecanoate
  • HY-W011637
    Methyl brassylate 1472-87-3 98.0%
    Methyl brassylate (Dimethyl tridecanedioate) is an ester product.
    Methyl brassylate
  • HY-W011786
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole 84946-20-3
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole is an inhibitor of larval settlement in marine organisms, demonstrating low toxicity while effectively inhibiting the metamorphosis of species such as barnacles, bryozoans, and polychaetes. 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole also exhibits activity as an aldose reductase (ALR2) inhibitor, indicating potential therapeutic applications in diabetes-related complications.
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
  • HY-W013187
    3-Methylcytidine methosulfate 21028-20-6 98%
    3-Methylcytidine (methosulfate), a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
    3-Methylcytidine methosulfate
  • HY-W013200
    Coumachlor 81-82-3 99.03%
    Coumachlor is an orally active antieoagulant agent. Coumachlor is a vitamin K antagonist.
    Coumachlor
  • HY-W013359
    Dimethyl dodecanedioate 1731-79-9 99.46%
    Dimethyl dodecanedioate is an ester product.
    Dimethyl dodecanedioate
  • HY-W014242
    2-(2-Chlorobenzamido)acetic acid 16555-60-5 98%
    2-(2-Chlorobenzamido)acetic acid is an aldose reductase inhibitor with an IC50 of 31 μM. 2-(2-Chlorobenzamido)acetic acid can be used for the research of chronic diabetes.
    2-(2-Chlorobenzamido)acetic acid
  • HY-W017431
    2,5-Dimethylbenzoic acid 610-72-0 98%
    2,5-Dimethylbenzoic acid is one of the main urinary metabolites of Pseudocumene (1,2,4-trimethylbenzene) in rats. 2,5-Dimethylbenzoic acid can be used to quantitatively determine the inhalation exposure level of Pseudocumene.
    2,5-Dimethylbenzoic acid
  • HY-W027126
    Hepatoprotective agent-2 74873-41-9 98%
    Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has antiapoptotic activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury.
    Hepatoprotective agent-2
  • HY-W037193
    Calcium Channel antagonist 5 21829-09-4 98%
    Calcium Channel antagonist 5 (compound 32) is a calcium channel antagonist with a pIC50 of 5.50.
    Calcium Channel antagonist 5
  • HY-W040074
    Glycylglycine hydrochloride hydrate 23273-91-8 98%
    Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis).
    Glycylglycine hydrochloride hydrate
  • HY-W040177
    VPC12249 ammonium 799268-73-8 98%
    VPC12249 (ammonium) is a phosphatidic acid.
    VPC12249 ammonium
  • HY-W040178
    VPC 32183 ammonium 799268-75-0 98%
    VPC 32183 (ammonium) is a phosphatidic acid.
    VPC 32183 ammonium
Cat. No. Product Name / Synonyms Application Reactivity